<div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div style="font-family:tahoma,sans-serif"><br><table cellspacing="0" cellpadding="0" width="100%" bgcolor="#474444" style="font-family:Arial,Helvetica,sans-serif"><tbody><tr><td style="font-size:0px;height:33px;line-height:0"></td></tr><tr><td valign="top"><table cellspacing="0" cellpadding="0" width="600" align="center" border="0" style="width:600px;margin:0px auto"><tbody><tr><th style="border-width:medium;border-style:none;border-color:initial;width:600px;font-weight:normal;padding:0px;text-align:left;background-color:rgb(254,251,251)"><table cellspacing="0" cellpadding="0" align="left" style="width:600px"><tbody><tr height="44" style="height:44px"><th style="border-width:medium;border-style:none;border-color:initial;width:477px;vertical-align:middle;font-weight:normal;padding:10px 0px 0px 10px;text-align:left;background-color:rgb(66,176,91)"><p align="left" style="margin-bottom:1em;font-size:14px;font-family:tahoma,geneva,sans-serif;color:rgb(253,251,251);margin-top:0px;line-height:18px;background-color:transparent"><strong> <span>Seminario</span> <span>IFEVA</span></strong></p></th><th style="border-width:medium;border-style:none;border-color:initial;width:103px;vertical-align:middle;font-weight:normal;padding:0px 5px;text-align:left;background-color:transparent"><div style="padding:10px;text-align:right"><table cellspacing="0" cellpadding="0" border="0" style="display:inline-block"><tbody><tr><td style="padding-right:5px"><a href="https://twitter.com/ifevaok?ref_src=twsrc%5Etfw%7Ctwcamp%5Eembeddedtimeline%7Ctwterm%5Eprofile%3Aifevaok&ref_url=http%3A%2F%2Fwww.ifeva.edu.ar%2Findex.tw.html" target="_blank"><img title="Twitter" alt="Twitter" src="https://mailchef.s3.amazonaws.com/uploads/mailstyler/images/478A2A14-0536-35C1-A7E4-6A014235947D_Image_1_9f1117f4-4654-4d62-878f-885c62b8fa59.png" width="24" 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style="border-width:medium;border-style:none;border-color:initial;width:580px;font-weight:normal;padding:0px 20px 0px 0px;text-align:left;background-color:rgb(254,251,251)"><table cellspacing="0" cellpadding="0" align="left" style="width:580px"><tbody><tr height="92" style="height:92px"><th style="border-width:medium;border-style:none;border-color:initial;width:580px;vertical-align:middle;font-weight:normal;padding:0px;text-align:left;background-color:transparent"><table cellspacing="0" cellpadding="0" align="center" border="0" style="margin:0px auto"><tbody><tr><td align="center" style="padding:0px"><table cellspacing="0" cellpadding="0" border="0"><tbody><tr><td style="border-width:medium;border-style:none;border-color:initial;background-color:transparent"><img alt="" src="https://mailchef.s3.amazonaws.com/uploads/mailstyler/images/152EFEE1-9961-67DB-42C9-BDFED3ECD20D_Image_4_2f0431fb-1968-435e-bed4-e7fa8fc21754.png" width="570" hspace="0" vspace="0" style="border-width:medium;border-style:none;border-color:initial;display:block"></td></tr></tbody></table></td></tr></tbody></table></th></tr></tbody></table></th></tr><tr><th style="border-width:medium;border-style:none;border-color:initial;width:600px;font-weight:normal;padding:0px;text-align:left;background-color:rgb(254,251,251)"><table cellspacing="0" cellpadding="0" align="left" style="width:600px"><tbody><tr height="76" style="height:76px"><th style="border-width:medium;border-style:none;border-color:initial;width:326px;vertical-align:middle;font-weight:normal;padding:10px 10px 0px 20px;text-align:left;background-color:rgb(243,54,62)"><p align="left" style="margin-bottom:1em;font-size:14px;font-family:tahoma,geneva,sans-serif;color:rgb(253,251,251);margin-top:0px;line-height:18px;background-color:transparent"><strong>VIERNES<br>28 de ABRIL 2023<br>12.00 hs</strong></p></th><th style="border-width:medium;border-style:none;border-color:initial;width:244px;vertical-align:middle;font-weight:normal;padding:10px 0px 0px;text-align:left;background-color:rgb(108,108,108)"><p align="center" style="margin-bottom:1em;font-size:14px;font-family:tahoma,geneva,sans-serif;color:rgb(56,56,56);text-align:center;margin-top:0px;line-height:18px;background-color:transparent"><a title="" href="https://www.youtube.com/channel/UCCC_QmqL9yuKBnZ6p4mnxBw" style="color:rgb(253,251,251);text-decoration-line:none" target="_blank">Presencial: SUM <strong><span>IFEVA</span></strong></a></p></th></tr></tbody></table></th></tr><tr><th style="border-width:medium;border-style:none;border-color:initial;width:600px;font-weight:normal;padding:0px;text-align:left;background-color:rgb(254,251,251)"><table cellspacing="0" cellpadding="0" align="left" style="width:600px"><tbody><tr height="121" style="height:121px"><th style="border-width:medium;border-style:none;border-color:initial;width:600px;vertical-align:middle;font-weight:normal;padding:0px;text-align:left;background-color:transparent"><table cellspacing="0" cellpadding="0" align="center" border="0" style="margin:0px auto"><tbody><tr><td align="center" style="padding:0px"><table cellspacing="0" cellpadding="0" border="0"><tbody><tr><td style="border-width:medium;border-style:none;border-color:initial;background-color:transparent"><img alt="" src="https://mailchef.s3.amazonaws.com/uploads/mailstyler/images/A1D4E880-2191-4DD7-2282-E4EBD8D61287_Image_5_91564d99-8f65-4b8d-9d26-1320ac7ed277.jpg" width="600" hspace="0" vspace="0" style="border-width:medium;border-style:none;border-color:initial;display:block"></td></tr></tbody></table></td></tr></tbody></table></th></tr></tbody></table></th></tr><tr><th style="border-width:medium;border-style:none;border-color:initial;width:600px;font-weight:normal;padding:10px 0px 5px;text-align:left;background-color:rgb(253,251,251)"><table cellspacing="0" cellpadding="0" align="left" style="width:600px"><tbody><tr height="126" style="height:126px"><th style="border-width:medium;border-style:none;border-color:initial;width:54px;vertical-align:top;font-weight:normal;padding:10px 5px 5px;text-align:left;background-color:transparent"><span class="gmail_default" style="font-family:tahoma,sans-serif"></span><table cellspacing="0" cellpadding="0" align="center" border="0" style="margin:0px auto"><tbody><tr><td align="center" style="padding:0px"><table cellspacing="0" cellpadding="0" border="0"><tbody><tr><td style="border-width:medium;border-style:none;border-color:initial;background-color:transparent"><img alt="" src="https://mailchef.s3.amazonaws.com/uploads/mailstyler/images/5A4A5834-3F9A-6A31-826B-CB9282750DB7_Image_6_f652f2ce-f80b-4f92-bd91-eb57b875ac83.png" width="18" hspace="0" vspace="0" style="border-width:medium;border-style:none;border-color:initial;display:block"></td></tr></tbody></table></td></tr></tbody></table></th><th style="border-width:medium;border-style:none;border-color:initial;width:526px;vertical-align:top;font-weight:normal;padding:5px;text-align:left;background-color:transparent"><p align="left" style="margin-bottom:1em;font-size:24px;font-family:tahoma,geneva,sans-serif;color:rgb(0,0,0);margin-top:0px;line-height:30px;background-color:transparent">Evidencia de inmunidad hereditaria por pararetrovirus endogenizados de tomate.</p></th></tr></tbody></table></th></tr><tr><th style="border-width:medium;border-style:none;border-color:initial;width:600px;font-weight:normal;padding:5px 0px;text-align:left;background-color:rgb(254,251,251)"><table cellspacing="0" cellpadding="0" align="left" style="width:600px"><tbody><tr height="564" style="height:564px"><th style="border-width:medium;border-style:none;border-color:initial;width:570px;vertical-align:top;font-weight:normal;padding:10px 15px;text-align:left;background-color:transparent"><p align="left" style="margin-bottom:1em;font-family:tahoma,geneva,sans-serif;color:rgb(56,56,56);margin-top:0px;line-height:20px;background-color:transparent"><font size="4"><strong><span style="color:rgb(66,176,91)">Autor:</span></strong> Diego H. <span>Sánchez</span></font></p><p align="left" style="margin-bottom:1em;font-family:tahoma,geneva,sans-serif;color:rgb(56,56,56);margin-top:0px;line-height:20px;background-color:transparent"><font size="4"><strong><span style="color:rgb(66,176,91)">Afiliación:</span></strong> <span>IFEVA</span> (CONICET-UBA), Facultad de Agronomía, Universidad de Buenos Aires.</font></p><p align="left" style="margin-bottom:1em;margin-top:0px;line-height:20px;background-color:transparent"><font size="4"><strong style="font-family:tahoma,geneva,sans-serif"><span style="color:rgb(66,176,91)">Resumen: </span></strong><span style="background-color:transparent">La genómica en eucariotas ha revelado consistentemente la existencia de eventos históricos de endogenización espontánea de elementos invasores externos, como son los virus. En vegetales, se cree que la ocurrencia de pararetrovirus endogenizados (</span><i style="background-color:rgb(255,255,255)">EPRV</i><span style="background-color:rgb(255,255,255)">) confiere una línea adicional de defensa anti-viral interna. Sin embargo, no existe demostración real de esta especulación. En este trabajo, analizamos el componente de </span><i style="background-color:rgb(255,255,255)">EPRV </i><span style="background-color:rgb(255,255,255)">en Solanum lycopersicum (tomate), junto con los efectores de silenciamiento asociados. Documentamos que ciertas integraciones pararetrovirales intrónicas/intergénicas llevan repeticiones invertidas que alimentan el sistema inmunitario, basado en pequeñas moléculas de ARN. Un conjunto sorprendentemente pequeño de reordenamientos cromosómicos explica una fracción sustancial de los ARN pequeños de interferencia derivados de pararetrovirus endogenizados, enriquecidos en formas de 22 nucleótidos que típicamente se asocian con el silenciamiento génico post-transcripcional. La transcripción adecuada de estos reordenamientos cromosómicos permitiría de evocar una respuesta de defensa. Proporcionamos evidencias preliminares de que tales señales genéticas e inmunológicas pueden encontrarse en otras especies fuera del género </span><i style="background-color:rgb(255,255,255)">Solanum</i><span style="background-color:rgb(255,255,255)">. Basados en datación molecular, bioinformática y exploraciones empíricas, proponemos que un fenómeno de silenciamiento dependiente de homología emerge de particulares áreas cromosómicas reorganizadas, las cuales constituirían un registro histórico adaptativo y hereditario de infecciones pasadas. Estas tendrían un impacto potencial contra el desbloqueo de </span><i style="background-color:rgb(255,255,255)">EPRV</i><span style="background-color:rgb(255,255,255)"> latentes y pararetrovirus libres.</span></font></p><p align="left" style="margin-bottom:1em;font-family:tahoma,geneva,sans-serif;color:rgb(56,56,56);margin-top:0px;line-height:20px;background-color:transparent"><font size="4"><strong><span style="color:rgb(66,176,91)">Palabras claves:</span></strong> defensas anti-virales, endogenización, pararetrovirus, tomate.</font></p></th></tr></tbody></table></th></tr><tr><th style="border-width:medium;border-style:none;border-color:initial;width:600px;font-weight:normal;padding:5px 0px;text-align:left;background-color:rgb(253,251,251)"><table cellspacing="0" cellpadding="0" align="left" style="width:600px"><tbody><tr height="163" style="height:163px"><th style="border-width:medium;border-style:none;border-color:initial;width:140px;vertical-align:top;font-weight:normal;padding:5px;text-align:left;background-color:transparent"><span class="gmail_default" style="font-family:tahoma,sans-serif"> </span><img src="cid:ii_kna7w23x0" alt="Diego Sanchez.jpg" width="105" height="105" style="margin-right:0px"><br></th><th style="border-width:medium;border-style:none;border-color:initial;width:440px;vertical-align:top;font-weight:normal;padding:5px;text-align:left;background-color:transparent"><p align="left" style="margin-bottom:1em;font-family:tahoma,geneva,sans-serif;color:rgb(56,56,56);margin-top:0px;line-height:18px;background-color:transparent"><font size="4"><strong>Diego H. <span>Sánchez</span></strong> o<span style="background-color:transparent;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;color:rgb(34,34,34)">riginalmente bioquímico, llevó a cabo la tesis doctoral en bioquímica y fisiología de plantas bajo estrés, seguida de varias instancias de estudios post-doctorales focalizados en biología de sistemas y análisis ómico, biología molecular, genética y bioinformática. Actualmente es Investigador Adjunto CONICET.</span></font></p><br></th></tr></tbody></table></th></tr><tr><th style="border-width:medium;border-style:none;border-color:initial;width:600px;font-weight:normal;padding:5px 0px;text-align:left;background-color:rgb(254,251,251)"><table cellspacing="0" cellpadding="0" align="left" style="width:600px"><tbody></tbody></table></th></tr><tr><th style="border-width:medium;border-style:none;border-color:initial;width:600px;font-weight:normal;padding:0px;text-align:left;background-color:rgb(229,229,229)"><table cellspacing="0" cellpadding="0" align="left" style="width:600px"><tbody><tr height="93" style="height:93px"><th style="border-width:medium;border-style:none;border-color:initial;width:570px;vertical-align:middle;font-weight:normal;padding:10px 10px 0px 20px;text-align:left;background-color:transparent"><p align="left" style="margin-bottom:1em;font-size:14px;font-family:verdana,arial,helvetica,sans-serif;color:rgb(56,56,56);margin-top:0px;line-height:18px;background-color:transparent"><span style="line-height:18px"><strong>Certificados:</strong> </span><span style="background-color:transparent;font-family:Arial,Helvetica,sans-serif;font-size:small;color:rgb(34,34,34)">los alumnos que necesiten certificar su asistencia, deberán enviar </span><span style="background-color:transparent;font-size:small">su nombre y DNI</span><span class="gmail_default" style="background-color:transparent;font-size:small;font-family:tahoma,sans-serif"> </span><span class="gmail_default" style="background-color:transparent;font-size:small;font-weight:700;font-family:tahoma,sans-serif"><span style="font-weight:normal">al moderador (</span><a href="mailto:mtexeira@agro.uba.ar" style="font-weight:normal" target="_blank">mtexeira@agro.uba.ar</a><span style="font-weight:normal">) </span>durante el transcurso del <span>seminario</span> o en la hora posterior a la finalización del mismo</span><span style="background-color:transparent;font-size:small">. </span></p></th></tr></tbody></table></th></tr><tr><th style="border-width:medium;border-style:none;border-color:initial;width:600px;font-weight:normal;padding:0px;text-align:left;background-color:rgb(66,176,91)"><table cellspacing="0" cellpadding="0" align="left" style="width:600px"><tbody><tr height="62" style="height:62px"><th style="border-width:medium;border-style:none;border-color:initial;width:560px;vertical-align:top;font-weight:normal;padding:25px 20px 10px;text-align:left;background-color:transparent"><p align="center" style="margin-bottom:1em;font-size:12px;font-family:tahoma,geneva,sans-serif;color:rgb(9,9,9);text-align:center;margin-top:0px;line-height:15px;background-color:transparent"><strong><span style="color:rgb(255,255,255)">Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura</span></strong></p></th></tr></tbody></table></th></tr><tr><th style="border-width:medium;border-style:none;border-color:initial;width:600px;font-weight:normal;padding:1px 0px;text-align:left;background-color:transparent"><table cellspacing="0" cellpadding="0" align="left" style="width:600px"><tbody><tr height="66" style="height:66px"><th style="border-width:medium;border-style:none;border-color:initial;width:590px;vertical-align:middle;font-weight:normal;padding:5px;text-align:left;background-color:transparent"><p align="center" style="margin-bottom:1em;font-size:12px;font-family:tahoma,geneva,sans-serif;color:rgb(253,251,251);text-align:center;margin-top:0px;line-height:15px;background-color:transparent"><br><span>IFEVA</span> - Facultad de Agronomía - Universidad de Buenos Aires<br> Av. San Martín 4453 - C1417DSE - Buenos Aires - Argentina</p></th></tr></tbody></table></th></tr></tbody></table></td></tr><tr><td style="font-size:0px;height:8px;line-height:0"> </td></tr></tbody></table><div><span style="font-family:Arial,Helvetica,sans-serif"><font color="#666666"><br></font></span></div><div><font color="#666666"><span style="font-family:Arial,Helvetica,sans-serif">--</span><br></font></div></div><div dir="ltr" data-smartmail="gmail_signature"><div dir="ltr"><div><font color="#666666">Marcos Texeira<br>Departamento de Métodos Cuantitativos y Sistemas de Información // <br>LART - IFEVA - CONICET<br>Facultad de Agronomía<br></font></div><div><font color="#666666">Universidad de Buenos Aires</font></div><div><span><br></span></div></div></div></div>
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